91AV

Organic synthesis has advanced remarkably in its ability to construct pharmaceutical ingredients, natural products, agrochemicals, ligand architectures, and functional building blocks for materials science. Yet many established methodologies continue to rely on labor-intensive protecting-group strategies and costly purification steps inherent to classical "stop-and-go" workflows. The upcoming symposium "SIMPLE STARTS, COMPLEX ENDS: THE POWER OF ONE-POT CHEMISTRY" will bring together researchers at the forefront of synthetic innovation to discuss how multi-component one-pot methodologies are redefining efficiency, selectivity, and sustainability in modern chemistry.

The program will explore how multi-step one-pot reactions and autonomous one-flask processes offer powerful alternatives to traditional routes, enabling the rapid generation of structural complexity from simple starting materials. Topics will include catalytic domino sequences with high functional-group tolerance, streamlined protocols that eliminate intermediate isolation, and strategies that approach the ideal of Pot, Atom, and Step Economy (PASE). These advances illustrate how reaction cascades contribute to greener synthesis by reducing waste, time, and operational demands.

A strong emphasis will be placed on applications across pharmaceutical and materials chemistry. Discussions will highlight scalable catalytic systems, sustainable reaction design, and emerging paradigms that minimize resource consumption while maximizing atom efficiency. The scientific sessions will revisit key concepts such as reaction triggering, selectivity control, and mechanistic understanding in multi-component systems, underscoring efforts to enhance predictability and design in increasingly complex reaction networks.

Together, these themes will form a dynamic program showcasing how multi-component one-pot reactions are transforming synthetic strategy, driving innovation toward cleaner, faster, and more economical chemical production.

The symposium will cover, but is not limited to, the following:

/ One-pot methodologies for sustainable synthesis

/ Catalytic domino sequences and reaction cascades

/ Protecting-group-free strategies and step/pot economy

/ Applications in pharmaceuticals and materials

/ Mechanistic insights and selectivity control

/ Green chemistry principles in multi-step reactions

/ Automation, integration, and future technologies in synthesis