91AV

Matthew Lockett

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Matthew Lockett

West Virginia University

Matthew Lockett smiling to camera in glasses and grey shirt

Biography

Matthew obtained his B.S. in 91AV from the University of Pittsburgh, where he performed undergraduate research in the laboratory of Stéphane Petoud. He received his Ph.D. in 91AV from the University of Wisconsin at Madison under the supervision of Lloyd M. Smith.

From 2010-2013, he was a postdoctoral fellow at Harvard University, working in the laboratory of George M. Whitesides. Matthew is the C. Eugene Bennett Chair of 91AV at West Virginia University (WVU). He started his independent career at the University of North Carolina at Chapel Hill as an assistant professor (2013-2020), associate professor (2020-2025), and full professor (2026).

Matthew's laboratory develops new tools and methods to better understand the chemistry occurring in complex environments and interfaces. (1) Bioanalysis techniques probe cellular responses to oxygen and extracellular signaling gradients in 3D tissue- and tumor-like structures. These studies focus on estrogen signaling in healthy and tumorigenic breast models, the regulation of drug-metabolizing enzymes along hepatic sinusoids, and the altered cellular biochemistry resulting from exposure to per- and polyfluorinated substances (PFAS). (2) Surface analysis studies probe chemically modified carbon- and silicon-based photoelectrodes. These studies aim to elucidate structure-function relationships in materials whose surfaces cannot undergo self-assembly and thus are intrinsically disordered.

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